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pentobarbital will decrease the extent or outcome of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Pitolisant publicity is reduced by 50% if coadministered with robust CYP3A4 inducers.pentobarbital will minimize the extent or result of etravirine by impacting hepatic/intestinal enzyme CYP3A4